My favorite comedian right now is Brian Regan. I don't even know why, exactly, but he reduces me to giggles that knock the breath right out of me. He sets it up perfectly, but I think it's partly his voice that just gets to me.
It's the kind of humor that gets even better with repetition, too.
Here's a duo, taken from "Stupid in School" and animated in a basic way.
Cup of Dirt